Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity

• Hauptverfasser: Rachel W. Linnemann (Verfasst von), Ruchi Yadav (Verfasst von), Chao Zhang (Verfasst von), Demba Sarr (Verfasst von), Balázs Rada (Verfasst von), Arlene A. Stecenko (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism by which neutrophils contribute to lung damage. The enzyme peptidylarginine deiminase 4 (PAD4) is required for N...