Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity

• Main Authors: Rachel W. Linnemann (Author), Ruchi Yadav (Author), Chao Zhang (Author), Demba Sarr (Author), Balázs Rada (Author), Arlene A. Stecenko (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism by which neutrophils contribute to lung damage. The enzyme peptidylarginine deiminase 4 (PAD4) is required for N...