Berberine Attenuates Macrophages Infiltration in Intracranial Aneurysms Potentially Through FAK/Grp78/UPR Axis

• Main Authors: Kai Quan (Author), Sichen Li (Author), Dongdong Wang (Author), Yuan Shi (Author), Zixiao Yang (Author), Jianping Song (Author), Yanlong Tian (Author), Yingjun Liu (Author), Zhiyuan Fan (Author), Wei Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Inflammatory cells, such as macrophages, play key roles in the pathogenesis of intracranial aneurysms (IAs). Berberine (BBR), an active component of a Chinese herb Coptis chinensis French, has been shown to have anti-inflammatory properties through suppressing macrophage migration in var...