Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

• Main Authors: Rofida Albash (Author), Noha M. Badawi (Author), Mohammed I. A. Hamed (Author), Maha H. Ragaie (Author), Sahar S. Mohammed (Author), Rovan M. Elbesh (Author), Khaled M. Darwish (Author), Manar O. Lashkar (Author), Sameh S. Elhady (Author), Shaimaa Mosallam (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) and then combine it with spironolactone (SP) in order to clinically compare the efficiency of both formulations against acne vulgaris. The BEO-loaded NPs formulatio...