Development and validation of an improved LC-MS/MS method for the quantification of desloratadine and its metabolite in human plasma using deutrated desloratadine as internal standard

• Main Authors: M Saquib Hasnain (Author), Shireen Rao (Author), Manoj Kr. Singh (Author), Nitin Vig (Author), Manish Kr. Singh (Author), Subodh Kr. Budakoti (Author), Abdulla Ansari (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: For the determination of desloratadine (DES) and 3-OH desloratadine (3-OHD) in human plasma using deutrated desloratadine (DESD5) as internal standard (IS), a novel stability indicating liquid chromatography-tandem mass spectrometric method was developed and validated to support the clinica...