Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs

• Main Authors: Gisele Barbosa (Author), Luis Gabriel Valdivieso Gelves (Author), Caroline Marques Xavier Costa (Author), Lucas Silva Franco (Author), João Alberto Lins de Lima (Author), Cristiane Aparecida-Silva (Author), John Douglas Teixeira (Author), Claudia dos Santos Mermelstein (Author), Eliezer J. Barreiro (Author), Lidia Moreira Lima (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combretastatin A-4 (CA-4, <b>1</b>) is an antimicrotubule agent used as a prototype for the design of several synthetic analogues with anti-tubulin activity, such as LASSBio-1586 (<b>2</b>). A series of branched and unbranched homologs of the lead-compound <b>2</b>...