Overcoming Hypoxia-Induced Chemoresistance in Cancer Using a Novel Glycoconjugate of Methotrexate

• Main Authors: Marta Woźniak (Author), Gabriela Pastuch-Gawołek (Author), Sebastian Makuch (Author), Jerzy Wiśniewski (Author), Piotr Ziółkowski (Author), Wiesław Szeja (Author), Monika Krawczyk (Author), Siddarth Agrawal (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The oxygen and nutrient-deprived tumor microenvironment is considered a key mechanism responsible for cancer resistance to chemotherapy. Methotrexate (MTX) is a widely incorporated chemotherapeutic agent employed in the treatment of several malignancies. However, drug resistance and systemic toxicit...