Optimizing Dacarbazine Therapy: Design of a Laser-Triggered Delivery System Based on β-Cyclodextrin and Plasmonic Gold Nanoparticles

• Main Authors: Sebastián Quintana-Contardo (Author), Orlando Donoso-González (Author), Erika Lang (Author), Ariel R. Guerrero (Author), Michael Noyong (Author), Ulrich Simon (Author), Marcelo J. Kogan (Author), Nicolás Yutronic (Author), Rodrigo Sierpe (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dacarbazine (DB) is an antineoplastic drug extensively used in cancer therapy. However, present limitations on its performance are related to its low solubility, instability, and non-specificity. To overcome these drawbacks, DB was included in β-cyclodextrin (βCD), which increased its aqueous solubi...