Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation

• Main Authors: Huan Yang (Author), Hui Liu (Author), Qiong Zeng (Author), Gavin H. Imperato (Author), Meghan E. Addorisio (Author), Jianhua Li (Author), Mingzhu He (Author), Kai Fan Cheng (Author), Yousef Al-Abed (Author), Helena E. Harris (Author), Sangeeta S. Chavan (Author), Ulf Andersson (Author), Kevin J. Tracey (Author)
• Format: Book
• Published: BMC, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products (RAGE). These pro-inflammatory complexe...