Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer

• Үндсэн зохиолчид: Salvatore Villani (Зохиогч), Giulia Dematteis (Зохиогч), Laura Tapella (Зохиогч), Mara Gagliardi (Зохиогч), Dmitry Lim (Зохиогч), Marco Corazzari (Зохиогч), Silvio Aprile (Зохиогч), Erika Del Grosso (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2023-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

In recent years, 4-phenylbutyric acid (4-PBA), an FDA-approved drug, has increasingly been used as a nonspecific chemical chaperone in vitro and in vitro, but its pharmacodynamics is still not clear. In this context, we developed and validated a Liquid Chromatography-High Resolution Mass Spectrometr...