A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

• Main Authors: Shengquan Hu (Author), Huihui Hu (Author), Shinghung Mak (Author), Guozhen Cui (Author), Mingyuen Lee (Author), Luchen Shan (Author), Yuqiang Wang (Author), Huangquan Lin (Author), Zaijun Zhang (Author), Yifan Han (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The over-activation of NMDA receptor via the excessive glutamate is believed to one of the most causal factors associated with Alzheimer's disease (AD), a progressive neurodegenerative brain disorder. Molecules that could protect against glutamate-induced neurotoxicity may hold therapeutic valu...