Exceptional response to lurbinectedin and irinotecan in -mutated platinum-resistant ovarian cancer patient: a case report

• Main Authors: Laura Cortesi (Author), Marta Venturelli (Author), Elena Barbieri (Author), Cinzia Baldessari (Author), Camilla Bardasi (Author), Emanuele Coccia (Author), Federica Baglio (Author), Margherita Rimini (Author), Stefano Greco (Author), Martina Napolitano (Author), Stefania Pipitone (Author), Massimo Dominici (Author)
• Format: Book
• Published: SAGE Publishing, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lurbinectedin is responsible for DNA recognition and binding, producing double-strand DNA (dsDNA) breaks thus resulting in apoptosis. Sensitivity to lurbinectedin is linked to the nucleotide excision repair (NER) system. Furthermore, irinotecan, a topoisomerase I inhibitor, provokes dsDNA breaks tha...