Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs capecitabine (CAP) and tegafur. Bioconversion of 5-FU prodrugs to 5-FU and subsequent metabolic activation of 5-FU are requ...

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Main Authors: Anthi Maslarinou (Author), Vangelis G. Manolopoulos (Author), Georgia Ragia (Author)
Format: Book
Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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