Downregulation of ADAM17 in pediatric immune thrombocytopenia impairs proplatelet formation

• Main Authors: Qi Wang (Author), Jia Wei (Author), Xi Jia (Author), Xiao Feng (Author), Zhenghua Ji (Author), Xueqiang Ji (Author), Xuejun Shao (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Immune thrombocytopenia (ITP) is the most common etiology of acquired thrombocytopenia diseases in children. ITP is characterized by the immune-mediated decreased formation and excessive destruction of platelets. The pathogenesis and management of pediatric ITP are distinct from...