The anticancer potential of thrombospondin-1 by inhibiting angiogenesis and stroma reaction during cervical carcinogenesis

• Main Authors: Ming-Ping Wu (Author), Li-Wha Wu (Author), Cheng-Yang Chou (Author)
• Formato: Libro
• Publicado: Wolters Kluwer Medknow Publications, 2016-05-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Tumor growth is angiogenesis dependent. Angiogenic switch (the acquisition of an angiogenic phenotype) is essential for cervical carcinogenesis. Thrombospondin-1 (TSP-1) is an endogenous angiogenic inhibitor with multiple functional domains and interacting receptors. The disruption of TSP-1 fence (t...