Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection

• Main Authors: Xin Zhang (Author), Xiulin Lin (Author), Hui Luo (Author), Yuanxing Zhi (Author), Xin Yi (Author), Xiaoyan Wu (Author), Wendi Duan (Author), Ying Cao (Author), Jianxin Pang (Author), Shuwen Liu (Author), Pingzheng Zhou (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging data have demonstrated the critical roles of potassium efflux in the innate immune system. However, the role of potassium efflux in TLR3/4 activation and type I interferon (IFN) responses are not well elucidated. In the present study, we found potassium efflux is essential for TLR3/4 signal...