GLP-1 Improves Adipocyte Insulin Sensitivity Following Induction of Endoplasmic Reticulum Stress

• Main Authors: Yaojing Jiang (Author), Zhihong Wang (Author), Bo Ma (Author), Linling Fan (Author), Na Yi (Author), Bin Lu (Author), Qinghua Wang (Author), Rui Liu (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Fag: article
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Glucagon-like peptide 1 (GLP-1) improves insulin resistance of adipose tissue in obese humans. However, the mechanism of this effect is unclear. Perturbation of endoplasmic reticulum (ER) homeostasis impairs insulin signaling. We hypothesized that GLP-1 could directly improve insulin signaling in ER...