Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release

• मुख्य लेखकों: Wei Li (लेखक), Jianhua Li (लेखक), Andrew E. Sama (लेखक), Haichao Wang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2013-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract The pathogen- and damage-associated molecular patterns (for example, bacterial endotoxin and adenosine 5'-triphosphate (ATP)) activate the double-stranded RNA-activated protein kinase R (PKR) to trigger the inflammasome-dependent high mobility group box 1 (HMGB1) release. Extracellular...