Serum Levels of Asymmetric Dimethylarginine and Apelin as Potential Markers of Vascular Endothelial Dysfunction in Early Rheumatoid Arthritis

• Main Authors: Manuela Di Franco (Author), Francesca Romana Spinelli (Author), Alessio Metere (Author), Maria Chiara Gerardi (Author), Virginia Conti (Author), Francesca Boccalini (Author), Cristina Iannuccelli (Author), Francesco Ciciarello (Author), Luciano Agati (Author), Guido Valesini (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives. Impaired endothelial function represents the early stage of atherosclerosis, which is typically associated with systemic inflammatory diseases like rheumatoid arthritis (RA). As modulators of endothelial nitric oxide synthase expression, asymmetric-dimethylarginine (ADMA) and apelin migh...