RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1

• المؤلفون الرئيسيون: Tom Skaria (مؤلف), Esther Bachli (مؤلف), Gabriele Schoedon (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2018-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of chronic inflammation, mediators secreted by activated immune cells or va...