Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound

• Main Authors: Yoko Endo-Takahashi (Author), Ryo Kurokawa (Author), Kanako Sato (Author), Nao Takizawa (Author), Fumihiko Katagiri (Author), Nobuhito Hamano (Author), Ryo Suzuki (Author), Kazuo Maruyama (Author), Motoyoshi Nomizu (Author), Norio Takagi (Author), Yoichi Negishi (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In brain-targeted delivery, the transport of drugs or genes across the blood−brain barrier (BBB) is a major obstacle. Recent reports found that focused ultrasound (FUS) with microbubbles enables transient BBB opening and improvement of drug or gene delivery. We previously developed nano-sized bubble...