Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound

• Главные авторы: Yoko Endo-Takahashi (Автор), Ryo Kurokawa (Автор), Kanako Sato (Автор), Nao Takizawa (Автор), Fumihiko Katagiri (Автор), Nobuhito Hamano (Автор), Ryo Suzuki (Автор), Kazuo Maruyama (Автор), Motoyoshi Nomizu (Автор), Norio Takagi (Автор), Yoichi Negishi (Автор)
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• Опубликовано: MDPI AG, 2021-07-01T00:00:00Z.
• Предметы: article
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In brain-targeted delivery, the transport of drugs or genes across the blood−brain barrier (BBB) is a major obstacle. Recent reports found that focused ultrasound (FUS) with microbubbles enables transient BBB opening and improvement of drug or gene delivery. We previously developed nano-sized bubble...