Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

• Main Authors: Sara Pereira (Author), Ruwei Yao (Author), Mariana Gomes (Author), Per Trolle Jørgensen (Author), Jesper Wengel (Author), Nuno Filipe Azevedo (Author), Rita Sobral Santos (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of bacterial resistance to traditional small-molecule antibiotics is fueling the search for innovative strategies to treat infections. Inhibiting the expression of essential bacterial genes using antisense oligonucleotides (ASOs), particularly composed of nucleic acid mimics (NAMs), ha...