Protective Effects of Magnesium Glycyrrhizinate on Methotrexate-Induced Hepatotoxicity and Intestinal Toxicity May Be by Reducing COX-2

• Main Authors: Yuzhu Cao (Author), Hang Shi (Author), Zhiguang Sun (Author), Jiawei Wu (Author), Yawen Xia (Author), Yufei Wang (Author), Yuanyuan Wu (Author), Xiaoman Li (Author), Wenxing Chen (Author), Aiyun Wang (Author), Yin Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese medicine Glycyrrhiza uralensis Fisch. Although the protective effects of MgIG on methotrexate (MTX)-induced liver toxici...