Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors

Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP, which can be further hydrolyzed by ecto-5'-nucleotidas...

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Main Authors: Laura Schäkel (Author), Constanze C. Schmies (Author), Riham M. Idris (Author), Xihuan Luo (Author), Sang-Yong Lee (Author), Vittoria Lopez (Author), Salahuddin Mirza (Author), The Hung Vu (Author), Julie Pelletier (Author), Jean Sévigny (Author), Vigneshwaran Namasivayam (Author), Christa E. Müller (Author)
Format: Book
Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
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3rd Floor Main Library

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