Condensation properties of stress granules and processing bodies are compromised in myotonic dystrophy type 1

• Main Authors: Selma Gulyurtlu (Author), Monika S. Magon (Author), Patrick Guest (Author), Panagiotis P. Papavasiliou (Author), Kim D. Morrison (Author), Alan R. Prescott (Author), Judith E. Sleeman (Author)
• Format: Book
• Published: The Company of Biologists, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases. Myotonic dystrophy type 1 (DM1) is a multi-systemic trinucleotide...