Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis

• Main Authors: Hiroshi Tsushima (Author), Shinji Morimoto (Author), Maki Fujishiro (Author), Yuko Yoshida (Author), Kunihiro Hayakawa (Author), Takuya Hirai (Author), Tomoko Miyashita (Author), Keigo Ikeda (Author), Ken Yamaji (Author), Kenji Takamori (Author), Yoshinari Takasaki (Author), Iwao Sekigawa (Author), Naoto Tamura (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA). CTGF consists of four distinct modules, including the insulin-like growth factor binding protein (IGFBP). In serum, insulin-like growth factor...