Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

• Main Authors: Pimonluck Sittikornpaiboon (Author), Pisanu Toochinda (Author), Luckhana Lawtrakul (Author)
• Formato: Libro
• Publicado: MDPI AG, 2017-09-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in the RCSB Protein Data Bank, but none of them is...