Paroxysmal extreme pain disorder M1627K mutation in human Na<sub>v</sub>1.7 renders DRG neurons hyperexcitable

Paroxysmal extreme pain disorder M1627K mutation in human Na<sub>v</sub>1.7 renders DRG neurons hyperexcitable

<p>Abstract</p> <p>Background</p> <p>Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function mutations in <it>SCN9A </it>which encodes voltage-gated sodium channel Na<sub...

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Main Authors: Tyrrell Lynda (Author), Jarecki Brian W (Author), Estacion Mark (Author), Dib-Hajj Sulayman D (Author), Fischer Tanya Z (Author), Lawden Mark (Author), Cummins Theodore R (Author), Waxman Stephen G (Author)
Format: Book
Published: SAGE Publishing, 2008-09-01T00:00:00Z.
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3rd Floor Main Library

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