A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

• 主要な著者: Elisa Rioja-Blanco (著者), Alberto Gallardo (著者), Irene Arroyo-Solera (著者), Patricia Álamo (著者), Isolda Casanova (著者), Ugutz Unzueta (著者), Naroa Serna (著者), Laura Sánchez-García (著者), Miquel Quer (著者), Antonio Villaverde (著者), Esther Vázquez (著者), Xavier León (著者), Lorena Alba-Castellón (著者), Ramon Mangues (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Loco-regional recurrences and metastasis represent the leading causes of death in head and neck squamous cell carcinoma (HNSCC) patients, highlighting the need for novel therapies. Chemokine receptor 4 (CXCR4) has been related to loco-regional and distant recurrence and worse patient prognosis. In t...