A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

• Main Authors: Elisa Rioja-Blanco (Author), Alberto Gallardo (Author), Irene Arroyo-Solera (Author), Patricia Álamo (Author), Isolda Casanova (Author), Ugutz Unzueta (Author), Naroa Serna (Author), Laura Sánchez-García (Author), Miquel Quer (Author), Antonio Villaverde (Author), Esther Vázquez (Author), Xavier León (Author), Lorena Alba-Castellón (Author), Ramon Mangues (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loco-regional recurrences and metastasis represent the leading causes of death in head and neck squamous cell carcinoma (HNSCC) patients, highlighting the need for novel therapies. Chemokine receptor 4 (CXCR4) has been related to loco-regional and distant recurrence and worse patient prognosis. In t...