Vascular α1A Adrenergic Receptors as a Potential Therapeutic Target for IPAD in Alzheimer's Disease

• Main Authors: Miles Frost (Author), Abby Keable (Author), Dan Baseley (Author), Amber Sealy (Author), Diana Andreea Zbarcea (Author), Maureen Gatherer (Author), Ho Ming Yuen (Author), Matt MacGregor Sharp (Author), Roy O. Weller (Author), Johannes Attems (Author), Colin Smith (Author), Paul R. Chiarot (Author), Roxana O. Carare (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drainage of interstitial fluid from the brain occurs via the intramural periarterial drainage (IPAD) pathways along the basement membranes of cerebral capillaries and arteries against the direction of blood flow into the brain. The cerebrovascular smooth muscle cells (SMCs) provide the motive force...