Tolvaptan induces body fluid loss and subsequent water conservation in normal rats

• Main Authors: Satoshi Kidoguchi (Author), Kento Kitada (Author), Yoshihide Fujisawa (Author), Daisuke Nakano (Author), Takashi Yokoo (Author), Jens Titze (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have recently reported that the urea osmolyte-associated water conservation system is activated in fluid loss models such as high salt-induced natriuresis, renal injury-induced impaired renal concentrating ability, or skin barrier dysfunction-induced transepidermal water loss. The system consists...