Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury

• Main Authors: Xiaoling Chen (Author), Jingliang Zhang (Author), KeWei Wang (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2022-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-d-aspartate (NMDA) receptors have failed to translate any clinical benefits, suggesting a non-NMDA mechanism involved in th...