Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer...
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Main Authors: | , , , , , , , |
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Format: | Book |
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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Internet
Connect to this object online.3rd Floor Main Library
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A1234.567 |
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Copy 1 | Available |