Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)

• Main Authors: Mahmoud G. Abo Al-Hamd (Author), Haytham O. Tawfik (Author), Omeima Abdullah (Author), Koki Yamaguchi (Author), Masaharu Sugiura (Author), Ahmed B. M. Mehany (Author), Mervat H. El-Hamamsy (Author), Tarek F. El-Moselhy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer...