Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)

Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showed moderate to good activity against NCI 60 cancer...

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Main Authors: Mahmoud G. Abo Al-Hamd (Author), Haytham O. Tawfik (Author), Omeima Abdullah (Author), Koki Yamaguchi (Author), Masaharu Sugiura (Author), Ahmed B. M. Mehany (Author), Mervat H. El-Hamamsy (Author), Tarek F. El-Moselhy (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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