Indene-Derived Hydrazides Targeting Acetylcholinesterase Enzyme in Alzheimer's: Design, Synthesis, and Biological Evaluation

• Главные авторы: Shraddha Manish Gupta (Автор), Ashok Behera (Автор), Neetesh K. Jain (Автор), Devendra Kumar (Автор), Avanish Tripathi (Автор), Shailesh Mani Tripathi (Автор), Somdutt Mujwar (Автор), Jeevan Patra (Автор), Arvind Negi (Автор)
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• Опубликовано: MDPI AG, 2022-12-01T00:00:00Z.
• Предметы: article
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As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer's disease (AD), its inhibition is a promising approach for treating AD. Sulindac is an NSAID of the aryl alkanoic acid class, consisting of a indene moiety, which showed neuroprotective behavior in recent studies. In thi...