Indene-Derived Hydrazides Targeting Acetylcholinesterase Enzyme in Alzheimer's: Design, Synthesis, and Biological Evaluation

• Main Authors: Shraddha Manish Gupta (Author), Ashok Behera (Author), Neetesh K. Jain (Author), Devendra Kumar (Author), Avanish Tripathi (Author), Shailesh Mani Tripathi (Author), Somdutt Mujwar (Author), Jeevan Patra (Author), Arvind Negi (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer's disease (AD), its inhibition is a promising approach for treating AD. Sulindac is an NSAID of the aryl alkanoic acid class, consisting of a indene moiety, which showed neuroprotective behavior in recent studies. In thi...