Dapagliflozin Attenuates Myocardial Fibrosis by Inhibiting the TGF-β1/Smad Signaling Pathway in a Normoglycemic Rabbit Model of Chronic Heart Failure

• Main Authors: Xuefeng Chen (Author), Qian Yang (Author), Wenlou Bai (Author), Wenjing Yao (Author), Litian Liu (Author), Yuanyuan Xing (Author), Cunliang Meng (Author), Peng Qi (Author), Yi Dang (Author), Xiaoyong Qi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have shown that sodium-glucose cotransporter-2 (SGLT2) inhibitors play a beneficial role for normoglycemic patients with heart failure (HF). However, the underlying mechanism remains largely unexplored. In the present study, we aimed to investigate the cardioprotective effect of SGLT2...