The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies

• Main Authors: Jiaqi Ren (Author), Linlin Lv (Author), Xufeng Tao (Author), Xiaohan Zhai (Author), Xuyang Chen (Author), Hao Yu (Author), Xinya Zhao (Author), Xin Kong (Author), Zhan Yu (Author), Deshi Dong (Author), Jing Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CBL-b, and CBL-c. Numerous studies have demonstrated...