Differentiation-Inducing Factor-1 Suppresses the Expression of c-Myc in the Human Cancer Cell Lines

• Main Authors: Kentaro Jingushi (Author), Toshihisa Nakamura (Author), Fumi Takahashi-Yanaga (Author), Etsuko Matsuzaki (Author), Yutaka Watanabe (Author), Tatsuya Yoshihara (Author), Sachio Morimoto (Author), Toshiyuki Sasaguri (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Differentiation-inducing factor-1 (DIF-1), a morphogen for Dictyostelium discoideum, inhibits the proliferation of human cancer cell lines by suppressing the Wnt/β-catenin signaling pathway. In this study, we examined the effect of DIF-1 on c-Myc, a target gene product of the Wnt/β-catenin signaling...