VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9

• প্রধান লেখক: Claudia Montagna (লেখক), Gianluca Petris (লেখক), Antonio Casini (লেখক), Giulia Maule (লেখক), Gian Marco Franceschini (লেখক), Ilaria Zanella (লেখক), Luciano Conti (লেখক), Francesca Arnoldi (লেখক), Oscar R. Burrone (লেখক), Lorena Zentilin (লেখক), Serena Zacchigna (লেখক), Mauro Giacca (লেখক), Anna Cereseto (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2018-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The method of delivery of CRISPR-Cas9 into target cells is a strong determinant of efficacy and specificity in genome editing. Even though high efficiency of Cas9 delivery is necessary for optimal editing, its long-term and high levels of expression correlate with increased off-target activity. We d...