Vaccine-induced CD8 T cells are redirected with peptide-MHC class I-IgG antibody fusion proteins to eliminate tumor cells in vivo

• Main Authors: Cornelia Fischer (Author), Michael W. Munks (Author), Ann B. Hill (Author), Richard A. Kroczek (Author), Stefan Bissinger (Author), Verena Brand (Author), Martina Schmittnaegel (Author), Sabine Imhof-Jung (Author), Eike Hoffmann (Author), Frank Herting (Author), Christian Klein (Author), Hendrik Knoetgen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Simulating a viral infection in tumor cells is an attractive concept to eliminate tumor cells. We previously reported the molecular design and the in vitro potency of recombinant monoclonal antibodies fused to a virus-derived peptide MHC class I complex that bypass the peptide processing and MHC loa...