Potentiation of Antibiotic Activity of Aztreonam against Metallo-β-Lactamase-Producing Multidrug-Resistant <i>Pseudomonas aeruginosa</i> by 3-<i>O</i>-Substituted Difluoroquercetin Derivatives

• Main Authors: Seongyeon Lee (Author), Taegum Lee (Author), Mi Kyoung Kim (Author), Joong Hoon Ahn (Author), Seri Jeong (Author), Ki-Ho Park (Author), Youhoon Chong (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The combination of aztreonam (ATM) and ceftazidime-avibactam (CAZ-AVI; CZA) has shown therapeutic potential against serine-β-lactamase (SBL)- and metallo-β-lactamase (MBL)-producing <i>Enterobacterales</i>. However, the ability of CZA to restore the antibiotic activity of ATM is severely...