Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

• Main Authors: Shilin Zhou (Author), Zanzhe Yu (Author), Zihui Chen (Author), Fengling Ning (Author), Xuetao Hu (Author), Tiangang Wu (Author), Mingxue Li (Author), Hong Xin (Author), Svetlana Reilly (Author), Xuemei Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and aims: Renal damage in severe coronavirus disease 2019 (COVID-19) is highly associated with mortality. Finding relevant therapeutic candidates that can alleviate it is crucial. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) have been shown to...