Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats
Background:Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synthetic opioid analgesic, is used to manage moderate to severe pain but has a high potential for abuse and dependence. Studies have shown that melatonin could be a potential modula...
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Frontiers Media S.A.,
2024-04-01T00:00:00Z.
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