Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver

• Główni autorzy: Bianca D. vanGroen (Autor), Chengpeng Bi (Autor), Roger Gaedigk (Autor), Vincent S. Staggs (Autor), Dick Tibboel (Autor), Saskia N. deWildt (Autor), J. Steven Leeder (Autor)
• Format: Książka
• Wydane: Wiley, 2020-05-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The hepatic influx transporter OATP1B1 (SLCO1B1) plays an important role in the disposition of endogenous substrates and drugs prescribed to children. Alternative splicing increases the diversity of protein products from > 90% of human genes and may be triggered by developmental signals. As conce...