A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

• Main Authors: Caroline De Souza Pereira (Author), Helenita Costa Quadros (Author), Samuel Yaw Aboagye (Author), Diana Fontinha (Author), Sarah D'Alessandro (Author), Margaret Elizabeth Byrne (Author), Mathieu Gendrot (Author), Isabelle Fonta (Author), Joel Mosnier (Author), Diogo Rodrigo M. Moreira (Author), Nicoletta Basilico (Author), David L. Williams (Author), Miguel Prudêncio (Author), Bruno Pradines (Author), Maribel Navarro (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hybrid-based drugs linked through a transition metal constitute an emerging concept for <i>Plasmodium</i> intervention. To advance the drug design concept and enhance the therapeutic potential of this class of drugs, we developed a novel hybrid composed of quinolinic ligands amodiaquine...