Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase

• Main Authors: Yuri V. Khramtsov (Author), Alexey V. Ulasov (Author), Tatiana N. Lupanova (Author), Tatiana A. Slastnikova (Author), Andrey A. Rosenkranz (Author), Egor S. Bunin (Author), Georgii P. Georgiev (Author), Alexander S. Sobolev (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a biologically active agent that provides the degradation of one of these key proteins and/or destroys the viral factory could suppress viral replication efficiently. The nucleocapsid protein (N-protein) is a...