Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats

• Main Authors: Ryoka Goto (Author), Shigehiro Yamada (Author), Hiroko Otake (Author), Yosuke Nakazawa (Author), Mikako Oka (Author), Naoki Yamamoto (Author), Hiroshi Sasaki (Author), Noriaki Nagai (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We developed ophthalmic formulations based on nilvadipine (NIL) nanocrystals (NIL-NP dispersions; mean particle size: 98 nm) by using bead mill treatment and investigated whether the instillation of NIL-NP dispersions delivers NIL to the lens and prevents lens opacification in hereditary cataractous...