Study on Acute Toxicity of Amiodarone New Complexes With Cyclodextrin

• Main Authors: Cristina Mihaela Ghiciuc (Author), Maytham Razaq Shleghm (Author), Cornelia Vasile (Author), Gladiola Tantaru (Author), Andreea Creteanu (Author), Lacramioara Ochiuz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amiodarone low solubility and high permeability is the limiting step for its bioavailability, therefore new formulations are needed to improve the solubility of amiodarone either to increase its oral bioavailability or to reduce its toxic effects. Complexation of amiodarone with cyclodextrin results...