Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

• Main Authors: Xiaohui Chen (Author), Meichun Gao (Author), Yongzhen Xia (Author), Xin Wang (Author), Jingbo Qin (Author), Hongying He (Author), Weirong Liu (Author), Xiaowei Zhang (Author), Shuangzhou Peng (Author), Zhiping Zeng (Author), Ying Su (Author), Xiaokun Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor cells. The pro-death effect of Nur77 can be regulated by its interaction with Bcl-2, resulting in conversion of Bcl-2 from a survival to killer. As Bcl-2 is overexpressed in various cancers preventing them f...