Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model.

• Main Authors: Erin Stebbins (Author), Rajiv S Jumani (Author), Connor Klopfer (Author), John Barlow (Author), Peter Miller (Author), Mary A Campbell (Author), Marvin J Meyers (Author), David W Griggs (Author), Christopher D Huston (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosporidium parvum infection of dairy calves, however,...