A novel tropically stable oral amphotericin B formulation (iCo-010) exhibits efficacy against visceral Leishmaniasis in a murine model.

• Main Authors: Ellen K Wasan (Author), Pavel Gershkovich (Author), Jinying Zhao (Author), Xiaohua Zhu (Author), Karl Werbovetz (Author), Richard R Tidwell (Author), John G Clement (Author), Sheila J Thornton (Author), Kishor M Wasan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30-43 °C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL).The stability testing of four novel oral lipid AmB formulations composed of mono- and di-gl...