Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

• Main Authors: Karl J. M. Hanf (Author), Joseph W. Arndt (Author), YuTing Liu (Author), Bang Jian Gong (Author), Mia Rushe (Author), Richelle Sopko (Author), Ramiro Massol (Author), Benjamin Smith (Author), Yan Gao (Author), Isin Dalkilic-Liddle (Author), Xinhua Lee (Author), Shanell Mojta (Author), Zhaohui Shao (Author), Sha Mi (Author), R. Blake Pepinsky (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81 (opicinumab), which blocks LINGO-1 function a...